TSP-1 in ME/CFS Pathogenesis
We propose that elevation of circulating thrombospondin-1 (TSP-1), a multifunction protein, in the blood could reduce brain-blood flow in some persons suffering from ME / CFS leading to a brain fog and post-exertional malaise (PEM). Conversely, a rapid decrease in TSP-1 blood levels in some ME / CFS patients could induce a hypotension resulting in orthostatic intolerance or even POTS.
Vascular instabilities are part of a group of symptoms affecting several persons with ME / CFS. Current treatments to alleviate those symptoms are limited and often not very effective for ME / CFS. A more comprehension approach about the role of TSP-1 in ME / CFS pathophysiology could lead to pharmacological therapies that are more effective.